association between serum biochemical levels, related to bone metabolism and parkinson’s disease

نویسندگان

rokhsareh meamar isfahan neurosciences research center, isfahan university of medical sciences and department of medical science, najafabad branch, islamic azad university, najafabad branch, isfahan, iran

mohammad maracy department of biostatistics and epidemiology, school of public health, isfahan university of medical sciences, isfahan, iran

ahmad chitsaz isfahan neurosciences research center and department of neurology, medical school, isfahan university of medical sciences, isfahan, iran

mohammad reza aghaye ghazvini isfahan center of health research, national institute of health research, tehran university of medical sciences, tehran, iran

چکیده

normal 0 false false false en-us x-none ar-sa background: vitamin d insufficiency and serum calcium disturbance have been reported to be more common in parkinson’s disease (pd) patients than in healthy control subjects, which may be due to a chronic disease or reduced mobility contributes to these relatively disturbances. because of the high-vitamin d insufficiency in our population, we aimed to compare a biochemical levels which are related to bone metabolism, in pd patients in comparison with age-matched healthy controls, for the 1 st time in a middle east population. materials and methods: this case-control study was involved 105 (20 were excluded) pd patients, who were age- and -sex matched with 112 controls. 25-hydroxyvitamin d ( 25ohd) and parathyroid hormone analyzed by enzyme immunoassay; another laboratory data including, calcium, phosphorous, and alkaline phosphatase were performed by spectrophotometric methods. results: there was no significant difference in 25ohd between pd patients and control group ( p = 0.071). 25ohd level was not significantly different in pd patients compared to controls {odds ratio 1.003, ( c onfidence interval [ci], 0.98-1.02), p value 0.793}. none of the other biochemical levels did not induce more chance for pd, only we observed in men has more risk of pd than women (odds ratio 2.53, [ci, 1.27-5.03], p value 0.008). conclusion: our data do not support a possible role of vitamin d insufficiency in pd. regarding to variable changes in biochemical markers in pd patients than in controls; further studies are suggested to determine any plausibility role of them as a causal relationship or as an outcome of pd.

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عنوان ژورنال:
journal of research in medical sciences

جلد ۱۸، شماره ۳، صفحات ۰-۰

کلمات کلیدی
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